Vishal Lamba - NextGen Sequencing
As one of the scientists who benefited from the incredible, almost century-long Human Genome Project, Vishal Lamba is quite excited about what could come next. The 2003 completion of the HGP inspired a different era of genome sciences, including the suddenly cheap yet very accurate genome analysis methods.
Fred Sanger’s Remarkable Work
It was Fred Sanger in 1977, who managed to sequence the first whole DNA genome, a virus phage called φX174. Remarkably, he did not rest on his laurels afterward, but experienced an even more profound eureka moment after he managed to develop what modern genome sequencing pretty much stems from; a method that relied on the process of chain termination. Almost immediately it was recognized as the first generation of genome sequencing technologies.
NextGen Sequencing Methods (NGS)
The truth is that scientist still pretty much rely on Sanger’s method, but what dramatically changed are the speed and the cost. Today, it is not only relatively cheap to use sequencing technologies, but it is also significantly faster and does not require extra manpower. NGS has an improved accuracy and is quicker, and there is no more need to have various scientists in the lab at the same time, just to finish a sequence. The reduced manpower further lowers the price, and the only problem that remains is the scientific interpretation of the findings, which is not an easy task to do. One has to consider the sheer numbers of those genes in addition to their functions, which could provide some much-needed answers.
Sources:
http://bitesizebio.com/21193/a-beginners-guide-to-next-generation-sequencing-ngs-technology/
Vishal Lamba - Three Reasons to Plan a Hike
Vishal Lamba enjoys going on hikes whenever he has free time. He is a scientist and an experienced professor who lives in Florida. He has spent years studying and working towards his professional goals. No matter how busy his schedule gets, he takes the time to plan a relaxing hike. Spending time outdoors can be a great way to relax and unwind. There are several reasons for you to plan a hike.
Hiking can be great exercise. If you pick a challenging trail, you will be working your way up a mountain. You may come across uneven terrain, and you may even need to do a little climbing. This activity is a good form of cardiovascular exercise. You can also work on the muscles in your legs and core while you make your way over uneven terrain.
A second reason is to enjoy nature. There are many beautiful hiking trails around the world. If you spend a day hiking, you may be able to see some rare wildlife and some amazing scenery. Many people who enjoy nature photography often spend time hiking.
A third reason is to relax. There are many individuals who have stressful jobs, and a hike can help them unwind after a busy week. Hiking can offer physical exercise and mental relaxation. Dr. Lamba loves a good hike. He hiked while he lived in Tennessee, Minnesota, and Florida. Dr. Vishal Lamba has a busy schedule and a long list of responsibilities. He relaxes by spending time outdoors and exploring different trails.
Vishal Lamba - How to Become a Scientist
Vishal Lamba has worked in Minnesota and Florida. He began his education in India, and moved to Tennessee to complete his training. He has multiple degrees, and is a dedicated scientist. He has taught courses in personalized medicine and pharmacology at the University of Minnesota as well as the University of Florida. He is dedicated to his research and enjoys building his knowledge of pharmacogenomics. If you want to become a scientist as well, there are a few steps that you will need to take.
The first step is to earn an undergraduate degree. While you are a student, you can explore different fields of science in order to find one that interests you. Some students choose to pursue the biosciences while others may be interested in environmental sciences. In the process of earning a Bachelor of Science, you may discover a field that you love.
The next step is to pursue an advanced degree. Some programs offer a joint Master of Science and a Doctor of Philosophy in the field of Pharmacogenomics (PhD), while others may only offer one or the other. A Master of Science will prepare you for your doctoral research.
If you want to build a career in science, you will need to earn a PhD. You will spend years focused on a single research project and complete a dissertation. While you are a graduate student, it may be helpful to build professional connections with professors and established professionals. Once you complete your dissertation, you will need to find a position with an established institution so that you can continue your research. Dr. Vishal Lamba has been a scientist for many years.
Vishal Lamba - Important Facts that are Related to Transcriptomics
Dr. Vishal Lamba has been working in science for many years. He studied pharmacogenomics and works with human genetics and pharmaceutical drugs. He worked at the University of Minnesota as well as the University of Florida. He has been involved in a number of research projects and is dedicated to his studies. He researches transcriptional and post-transcriptional mechanisms that are related to gene expression levels of hepatic drug metabolizing enzymes.
Transcriptomics is the study of transcriptome, which is the complete set of RNA transcripts that are produced by the human genome. The human genome is comprised of DNA, which contains the instructions that are necessary for the development and maintenance of cells. The DNA holds the instructions, however, those instructions cannot be carried out unless the DNA is read and then transcribed. As the DNA is transcribed, it is copied into RNA, which mirrors the original DNA. The transcribed RNA are referred to as transcripts. A collection of transcripts in a transcriptome.
There are many different kinds of RNA, and analyzing a cell’s entire collection of RNA can help scientists and researchers “determine when and where each gene is turned on or off in the cells and tissues of an organism.” Studying transcriptomes can help scientists determine the amount of gene activity in a certain cell type or tissue type. Data from the study of transcriptomes can demonstrate gene function and help researchers learn about the causes and effects of different gene activities. Dr. Vishal Lamba works with genetics and studies gene expressions.
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Vishal Lamba - What Your Genetics Say About You
Dr. Vishal Lamba earned a Doctor of Philosophy in the field of Pharmacogenomics from the University of Tennessee in 2008. He completed his research in pharmacogenomics and then went on to complete a post-doctoral fellowship at the University of Minnesota. Pharmacogenomics involves studying how genetics can affect an individual’s response to a drug. Dr. Lamba is interested in how genetics effect the metabolism of drugs and how patient’s respond to them. Genetics play an important role in medicine.
Genetics do not just determine the color of a person’s eyes or hair, but a person’s susceptibility to develop certain diseases as well. The Human Genome Project was completed in 2003 by the United States Department of Energy and the National Institute of Health after more than ten years of research. The human genome is made up of three billion units of DNA. The project focused on identifying the genes in this data. The project revealed that there are approximately twenty thousand and five hundred human genes, and the “completed human sequence can now identify their locations.” The project is important because it provided valuable information on the structure of genes, and how different genes function.
The Human Genome Project has helped medical professionals develop personalized medicine methods. Your genetics can determine whether or not you may develop a disease and how you will respond to generic treatments. Genetic knowledge can provide doctors with the tools and information they need to create a treatment plan that is most effective for their patients. Dr. Vishal Lamba works with genetics and studies how genetics affect how drugs are metabolized and their effectiveness.
Sources:
https://www.genome.gov/12011238/an-overview-of-the-human-genome-project/
http://health.usnews.com/health-conditions/cancer/personalized-medicine/overview
